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. 2015 Dec 18;16:149. doi: 10.1186/s12931-015-0309-0

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© Fan et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The effect of dmPGE₂ on human bronchial epithelial cell proliferation and induction of expression and activation of PDK1. a Effects on cell proliferation. b dmPGE₂ increases the phosphorylation and expression of PDK1 in a time- and dose-dependent manner in BEAS2B and HBEc14-KT cells. c PDK1 inhibitor OSU-03012 decreases cell proliferation induced by dmPGE₂ in normal bronchial epithelial cells. d PDK1 siRNA decreases the cell proliferation induced by dmPGE₂ in normal bronchial epithelial cells. e PDK1 plasmid increases the cell proliferation induced by dmPGE₂ in normal bronchial epithelial cells. f Effect on mRNA expression. g Effect on PDK1 promoter activity