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. 2015 Dec 18;16:149. doi: 10.1186/s12931-015-0309-0

Fig. 2.

Fig. 2

EP4 Mediates the Cell Proliferation and increased expression and activation of PDK1 induced by PGE2 in HBEc14-KT and BEAS2B cells. a EP4 antagonist AH23848 decreased the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. b EP4 siRNA decreases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. c EP4 antagonist AH23848 decreased the phosphorylation and expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. d EP4 siRNA decreased the phosphorylation and expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. e Effect on PDK1 promoter activity