Fig. 3.

c-Jun Mediates the Cell Proliferation and increased expression and activation of PDK1 induced by PGE₂ in HBEc14-KT and BEAS2B cells. a dmPGE₂ increases expression of c-Jun in a time- and dose-dependent manner in BEAS2B and HBEc14-KT cells. b c-Jun siRNA decreases the cell proliferation induced by dmPGE₂ in normal bronchial epithelial cells. c c-Jun plasmid increases the cell proliferation induced by dmPGE₂ in normal bronchial epithelial cells. d c-Jun siRNA decreases expression of PDK1 induced by dmPGE₂ in BEAS2B and HBEc14-KT cells. e c-Jun plasmid increases expression of PDK1 induced by dmPGE₂ in BEAS2B and HBEc14-KT cells. f Effect of c-Jun siRNA on PDK1 promoter activity. g Effect of c-Jun plasmid on PDK1 promoter activity. h Effects of c-Jun point-moutations on PDK1 promoter activity