Table 3.
Clinical and Laboratory Characteristics of VLBW Infants with Postnatal CMV Infection (n=328)
| Postnatal CMVa (n=328) | |
|---|---|
| Postnatal age at CMV diagnosis, days | |
| 21–34 | 20% |
| 35–60 | 54% |
| ≥61 | 27% |
| Postmenstrual age at CMV diagnosis, weeks | |
| ≤30 | 25% |
| 31–33 | 46% |
| ≥34 | 29% |
| Cardiorespiratory status | |
| Received ≥1 vasopressor medications | 12% |
| New requirement for vasopressor medications | 9% |
| Maximum level of respiratory support | |
| Room air | 6% |
| Nasal cannula oxygen or CPAP | 32% |
| Conventional mechanical ventilation | 45% |
| High-frequency ventilation | 18% |
| Required increased level of respiratory support | 25% |
| Required intubation for mechanical ventilation | 15% |
| Maximum FiO2 | |
| 21% | 8% |
| 22–50% | 51% |
| 51–100% | 41% |
| Required increased FiO2 | 58% |
| New oxygen requirement | 28% |
| Death | 1.2% |
| Laboratory abnormalities | |
| Absolute neutrophil count <1500 cells/μL | 34% |
| Absolute lymphocyte count <2500 cells/μL | 26% |
| Platelet count <100,000/μL | 66% |
| Transaminitisb | 16% |
| Direct bilirubin >1.0 mg/dL | 66% |
| Change in cardiorespiratory status or laboratory abnormality | 89% |
Abbreviations: VLBW, very low birth weight; CMV, cytomegalovirus; CPAP, continuous positive airway pressure; FiO2, fraction of inspired oxygen; μL, microliter; mg, milligram; dL, deciliter.
a
Percentages may not sum to total because of rounding.
b
Defined as aspartate transaminase (AST) >150 U/L and alanine aminotransferase (ALT) >90 U/L.