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. 2015 Dec 31;56(13):8438–8448. doi: 10.1167/iovs.15-17523

Figure 1.

Figure 1

Induction of PMU and EAU in rats. For PMU, a subcutaneous “systemic prime” of killed mycobacterium tuberculosis H37Ra is given on day −7. On day 0, uveitis is induced with an intravitreal injection of the killed mycobacterium extract in PBS. Ocular inflammation peaks on day 2 and resolves spontaneously by day 14. Experimental autoimmune uveitis is induced by immunization with IRBP peptide (ADGSSWEGVGVVPDV) in complete Freund's adjuvant on day 0. Ocular inflammation peaks on day 14 and spontaneously resolves on day 21. Ocular inflammation was assessed on days 2, 7, and 14 for PMU and days 2, 7, 14, and 21 for EAU. Naïve samples were collected from animals at day 0 in both models (*PMU Naïve; ‡EAU naïve).