Fig 9. Interspike-time and frequency-count histograms computed from a simulation of diffusive vesicles under an attractive harmonic potential and including a lag time Δt _fus at the membrane (see text) according to Ref. [35], before and after time-rescaling.

(A), (C) Interspike-time histograms f(δt) and f(δτ) before and after time rescaling, respectively. (B),(D) frequency-count histograms P(k) (for a time interval of T = 2.3 s width) and P(κ) (for a rescaled time interval of $\overline{\tau }=4.0$ width) before and after time rescaling, respectively. The histograms f(δt) and f(δτ) are fitted with gamma-(solid lines) and exponential distributions (dashed lines). The frequency-count histograms P(k) and P(κ) are fitted with the gamma-count (see text, solid lines) and Poisson distributions (dashed lines). The total number of spikes was 4257. Inset plots in (A) and (C) show the spike rates of the original and time rescaled spike series, respectively.