Table 2. Percentage change from baseline at treatment cycle 3 day 24 for carrier proteins, lipoproteins, bone biomarkers, and growth and steroid endocrine parameters (ITT population).
| Parameter |
5 mg E4/DRSP n = 17 |
10 mg E4/DRSP n = 19 |
20 μg EE/DRSP n = 20 |
5 mg E4/LNG n = 18 |
10 mg E4/LNG n = 17 |
20 mg E4/LNG n = 18 |
|---|---|---|---|---|---|---|
| SHBG | 7.9 (26.2) | 44.5 (34.1) | 306.3 (117.7) | − 69.0 (11.8) | − 64.8 (11.9) | − 44.2 (18.0) |
| CBG | 17.1 (16.6) | 28.1 (19.6) | 170.3 (75.6) | − 6.9 (17.2) | 5.9 (13.3) | 25.2 (25.0) |
| Ceruloplasmin | 8.2 (12.2) | 16.1 (11.1) | 69.0 (22.9) | − 5.4 (14.6) | 0.7 (9.9) | 16.2 (6.1) |
| HDL-cholesterol | 8.1 (14.0) | 5.6 (11.5) | 15.2 (11.3) | − 16.9 (20.7) | − 11.9 (14.1) | − 19.0 (10.9) |
| LDL-cholesterol | 6.7 (20.7) | 6.3 (18.3) | − 9.2 (22.1) | − 5.9 (16.1) | − 13.8 (20.2) | 8.9 (17.9) |
| Total cholesterol | 5.2 (9.8) | 5.0 (9.6) | 4.9 (10.3) | − 12.8 (9.1) | − 15.5 (14.4) | − 7.6 (9.1) |
| Triglycerides | 6.4 (36.7) | 10.0 (48.5) | 61.2 (51.2) | − 24.6 (33.7) | − 29.7 (26.5) | − 27.4 (16.5) |
| ASAT/SGOT | − 4.0 (11.9) | 2.0 (22.1) | − 9.6 (25.6) | − 11.6 (24.9) | − 12.4 (21.9) | − 13.3 (18.6) |
| Alkaline phosphatase | − 11.3 (6.6) | − 17.6 (8.6) | − 20.6 (11.8) | − 7.5 (12.5) | − 5.8 (14.9) | − 4.7 (12.5) |
| γGT | − 4.8 (18.5) | − 8.2 (14.6) | − 11.0 (20.9) | − 0.6 (19.8) | 3.6 (16.0) | 2.7 (17.7) |
| C-telopeptide | − 8.6 (16.8) | − 13.4 (20.2) | − 34.9 (17.8) | − 6.4 (22.5) | − 12.4 (23.0) | − 22.4 (18.8) |
| Osteocalcin | − 10.4 (11.1) | − 16.3 (11.9) | − 22.3 (11.7) | − 4.1 (16.6) | 0.8 (19.7) | − 13.0 (16.1) |
| IGF-I | − 5.9 (10.8) | − 11.5 (17.7) | − 41.9 (14.0) | 1.4 (7.4) | 3.4 (20.0) | − 8.8 (12.0) |
| IGF-II | − 0.7 (8.4) | − 2.3 (13.1) | 4.7 (7.7) | − 0.7 (9.4) | 4.8 (18.6) | − 2.2 (6.9) |
| IGFBP-1 | 21.1 (52.3) | 0.0 (30.6) | 190.9 (245.0) | − 7.5 (46.7) | 56.5 (251.5) | 41.9 (83.8) |
| IGFBP-3 | 7.4 (8.0) | 1.4 (11.0) | 3.9 (12.6) | 1.3 (12.4) | 2.0 (12.9) | 16.3 (11.0) |
| GH | 100.0 (191.6) | 314.1 (722.4) | 238.4 (508.4) | 173.9 (755.1) | 357.5 (750.3) | 467.7 (1191.3) |
Values are mean (SD) percentage change.