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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: Adv Mater. 2015 Aug 25;27(37):5547–5552. doi: 10.1002/adma.201502003

Figure 2. Retention of MMP pretreated responsive nanoparticles and clearance of nonresponsive nanoparticles in healthy myocardium.

Figure 2

MMP pretreated particles were injected into healthy rat myocardium (A) and tissue was evaluated 1 minute, 1 hour, 1 day, 2 days, and 7 days post-injection for presence of the fluorescent aggregates (B). Rhodamine labeled, responsive particles (B, top row) were observed at the site of injection up to 7 days post-injection, while the nonresponsive particles (B, bottom row) were cleared after 1 hour. Scale bar: 1 mm (A); 50 µm (B).