. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Biochem Pharmacol. 2015 Sep 5;98(3):493–501. doi: 10.1016/j.bcp.2015.09.002

Table 1. Accumulated endogenous metabolites in the liver of mice treated with GSF.

Liver samples were analyzed by UPLC-QTOFMS.

No.	Chemical Class	Identity	RT (min)	Observed m/z	Mass error	Formula
1	Porphyrins	PPIX	11.03	563.2654	−0.7	C₃₄H₃₄N₄O₄
2		N-methyl PPIX	11.85	577.2809	−1.0	C₃₅H₃₆N₄O₄
3	Bile acids	TCA	5.62	514.2838	0.0	C₂₆H₄₅NO₇S
4		TβMCA	4.99	514.2839	0.2	C₂₆H₄₅NO₇S
5		TαMCA	4.89	514.2841	0.6	C₂₆H₄₅NO₇S
6		TDCA	6.25	498.2891	0.4	C₂₆H₄₅NO₆S
7		TCDCA	6.18	498.2885	−0.8	C₂₆H₄₅NO₆S
8		TUDCA	5.52	498.2881	−1.6	C₂₆H₄₅NO₆S
9	Antioxidant	GSH	0.67	308.0913	−1.0	C₁₀H₁₇N₃O₆S

RT, retention time; ppm, part per million; PPIX, protoporphyrin IX; TCA, Taurocholic acid; TαMCA, Tauro-α-Muricholic acid; TβMCA, Tauro-β-Muncholic acid; TDCA, Tauro-deoxycholic acid, TCDCA, Tauro-Chenodeoxycholic Acid; TUDCA, Tauroursodeoxycholic acid; GSH, Glutathione.