Table S2.
Baseline characteristics: 40–90 years of age
| 40–49 (n=7) | 50–59 (n=77) | 60–69 (n=241) | 70–79 (n=159) | 80–90 (n=32) | P-value | |
|---|---|---|---|---|---|---|
| Sex, male | 7 (100) | 77 (97.5) | 227 (94.2) | 150 (94.3) | 27 (84.4) | 0.145 |
| BMI, kg/m2 | 20.86±3.28 | 23.57±2.82 | 22.84±3.37 | 21.72±3.07 | 21.94±3.94 | <0.001 |
| Smoking | 0.253 | |||||
| Current smoker | 3 (42.9) | 47 (59.5) | 105 (43.6) | 57 (35.8) | 7 (21.9) | |
| Former smoker | 3 (42.9) | 22 (27.8) | 102 (42.3) | 78 (49.1) | 19 (59.4) | |
| Never smoker | 1 (14.3) | 4 (5.1) | 13 (5.4) | 10 (6.3) | 5 (15.6) | |
| Unknown | 0 (0) | 6 (7.6) | 21 (8.7) | 14 (8.8) | 1 (3.1) | |
| Pack-year | 29.80±16.88 | 41.77±20.46 | 42.98±20.61 | 46.51±25.42 | 39.43±24.15 | 0.129 |
| GOLD | 0.219 | |||||
| I | 0 (0) | 7 (8.9) | 20 (8.3) | 16 (10.1) | 2 (6.3) | |
| II | 3 (42.9) | 34 (43.0) | 110 (45.6) | 67 (42.1) | 18 (56.3) | |
| III | 3 (42.9) | 29 (36.7) | 85 (35.3) | 65 (40.9) | 11 (34.4) | |
| IV | 1 (14.3) | 9 (11.4) | 26 (10.8) | 11 (6.9) | 1 (3.1) | |
| Post-bronchodilator | ||||||
| FVC, L | 3.58±0.47 | 3.72±0.81 | 3.35±0.85 | 3.18±0.78 | 2.75±0.75 | <0.001 |
| FVC, % | 80.71±11.73 | 83.43±15.89 | 80.91±17.35 | 79.01±16.67 | 75.09±13.81 | 0.128 |
| FEV1, L | 1.84±0.60 | 1.81±0.68 | 1.59±0.63 | 1.46±0.54 | 1.25±0.42 | <0.001 |
| FEV1, % | 50.57±17.06 | 52.14±18.04 | 52.17±18.56 | 53.09±18.65 | 55.41±15.81 | 0.890 |
| FEV1/FVC, % | 51.57±13.59 | 44.77±11.04 | 46.99±12.10 | 46.01±11.15 | 46.28±10.71 | 0.625 |
| Pre-bronchodilator | ||||||
| FVC, L | 3.40±0.53 | 3.53±0.89 | 3.19±0.88 | 3.04±0.80 | 2.60±0.76 | <0.001 |
| FVC, % | 76.71±12.69 | 79.06±17.75 | 77.01±18.32 | 75.62±17.63 | 71.22±15.70 | 0.285 |
| FEV1, L | 1.76±0.61 | 1.69±0.71 | 1.47±0.64 | 1.37±0.54 | 1.17±0.40 | <0.001 |
| FEV1, % | 48.14±17.31 | 48.68±19.10 | 48.29±18.88 | 49.58±19.07 | 51.53±14.92 | 0.891 |
| FEV1/FVC, % | 50.86±13.07 | 46.80±11.30 | 46.80±11.30 | 45.54±12.06 | 44.86±11.23 | 0.568 |
| Positive BDR | 0 (0) | 1 (1.3) | 14 (5.8) | 9 (5.7) | 1 (0) | 0.621 |
| History of acute exacerbation | 2 (28.6) | 16 (20.3) | 76 (31.5) | 60 (37.7) | 20 (62.5) | <0.001 |
| Follow-up months | 58.72±24.08 | 63.38±31.35 | 57.51±26.95 | 49.93±26.66 | 40.75±25.97 | <0.001 |
Note: Data presented as mean ± SD or n (%).
Abbreviations: BDR, bronchodilator response; BMI, body mass index; FEV1, forced expiratory volume in 1-second; FVC, forced vital capacity; GOLD, Global initiative for Chronic Obstructive Lung Disease.