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. 2015 Nov 2;35(1):26–32. doi: 10.3892/or.2015.4372

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Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of the changes in Cks1 and Cks2 protein levels on cell cycle in HepG2 cells. The statistical analysis showed that upregulation of Cks1 protein level increased the percentage of cells in S phase (P<0.01) and decreased the percentage of cells in G0/G1 and G2/M (P<0.01) compared to the control. Overexpression of Cks2 only increased the percentage of cells in G0/G1 (P<0.05) and decreased the percentage of cells in G2/M (P<0.01) compared to the control while the percentage of cells in S phase show no significant difference. The percentage of cells in each phase after Cks1 and Cks2 siRNA transfection was not significantly different from the control.