Table 1. Intrastrand and interstrand G-quadruplex sequences by human chromosome.
Chromosome | Unique interstrand | Intrastrand | Intra/inter | ||
---|---|---|---|---|---|
count | per MB | count | per MB | ratio | |
Genome wide | 550,977 | 177.98 | 374,834 | 121.08 | 0.68 |
chr1 | 48,860 | 196.03 | 32,597 | 130.78 | 0.67 |
chr2 | 39,032 | 160.49 | 26,826 | 110.30 | 0.69 |
chr3 | 26,696 | 134.81 | 18,839 | 95.14 | 0.71 |
chr4 | 21,369 | 111.79 | 15,358 | 80.34 | 0.72 |
chr5 | 24,701 | 136.53 | 17,587 | 97.21 | 0.71 |
chr6 | 22,788 | 133.17 | 16,675 | 97.45 | 0.73 |
chr7 | 28,578 | 179.58 | 19,372 | 121.73 | 0.68 |
chr8 | 22,872 | 156.27 | 15,750 | 107.61 | 0.69 |
chr9 | 26,855 | 190.17 | 17,522 | 124.08 | 0.65 |
chr10 | 26,533 | 195.77 | 17,420 | 128.53 | 0.66 |
chr11 | 30,587 | 226.56 | 19,984 | 148.02 | 0.65 |
chr12 | 23,132 | 172.82 | 16,330 | 122.00 | 0.71 |
chr13 | 11,244 | 97.63 | 7,802 | 67.74 | 0.69 |
chr14 | 17,177 | 160.01 | 11,311 | 105.37 | 0.66 |
chr15 | 17,585 | 171.51 | 11,733 | 114.43 | 0.67 |
chr16 | 25,607 | 283.41 | 16,495 | 182.56 | 0.64 |
chr17 | 29,171 | 359.27 | 18,897 | 232.74 | 0.65 |
chr18 | 10,458 | 133.94 | 7,474 | 95.73 | 0.71 |
chr19 | 30,206 | 510.85 | 20,794 | 351.67 | 0.69 |
chr20 | 17,655 | 280.12 | 11,496 | 182.40 | 0.65 |
chr21 | 7,857 | 163.25 | 4,848 | 100.73 | 0.62 |
chr22 | 18,280 | 356.30 | 10,420 | 203.10 | 0.57 |
chrX | 20,295 | 130.71 | 16,468 | 106.06 | 0.81 |
chrY | 3,436 | 57.87 | 2,832 | 47.70 | 0.82 |
For each chromosome in the human nuclear genome (v. hg19), the numbers of intrastrand and interstrand potentially quadruplex-forming sequences are listed. Sequences with loops up to 7nt long and at least three guanines per tract are considered. In case of overlapping interstrand quadruplexes, only one is taken into account (unique DS-PQS).