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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Virology. 2014 Dec 18;476:61–71. doi: 10.1016/j.virol.2014.11.022

Fig 5. Functional motifs of MVM NS1N.

Fig 5

(a) Functional motifs mapped onto the MVM NS1N structure. Nuclear localization signal (NLS) (residues 194–195 and 214–216), blue. Acetylation site (Lys85), cyan. Predicted cyclin-dependent kinase (CDK) phosphorylation site (residues 219–223), red. The potential Akt/PKB phosphorylation site at residue Thr278 is located in a region immediately after the C-terminus of the nickase domain (dashed curve). The nickase active site residues are shown in magenta. The putative Ori-binding site (loop L10) overlaps with the NLS and is partially in gold. The N- and C- termini are indicated.

(b) A crystallographic dimer of MVM NS1N view down the 2-fold axis showing that the first element in the NLS, Lys194-195, is adjacent to the second element (Lys214-216) in the NLS from a two-fold-related molecule.