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Permeability assessments were collected from the undamaged colon at 1-5 days after urinary bladder infusion of protamine sulfate. The colonic TEER was significantly decreased at all time points (A-C), and the colonic macromolecular flux significantly increased at all time points (E-F) (*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001) compared to controls. At each time point, rats n = 5-7/group were used.
