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. 2016 Jan 30;22(1):141–148. doi: 10.5056/jnm15036

Table 2.

Relaxation Responses Expressed As a Percentage of the Tone of the Tissue at the Time of Stimulation.

Drug/frequency Relaxation (% of baseline) Inhibition (% of control response)

Absence of drug Presence of drug
L-NNA (100 μM, n = 26) 5 Hz 56.6 ± 2.2 32.8 ± 2.8a 42.6 ± 4.2
10 Hz 45.4 ± 3.7 19.9 ± 2.9a 60.4 ± 4.9
Indomethacin (5 μM, n = 14) 5 Hz 44.9 ± 3.7 44.0 ± 3.6 1.7 ± 2.7
10 Hz 47.1 ± 4.2 45.4 ± 4.5 4.5 ± 4.1
PheLeu-VIP (100 nM, n = 6) 5 Hz 50.0 ± 4.2 48.0 ± 3.9 3.5 ± 2.5
10 Hz 52.6 ± 4.9 52.0 ± 4.3 0.7 ± 2.2
a

P < 0.001 compared to response in the absence of drug.

L-NNA, Nω-nitro-L-arginine; PheLeu-VIP, [d-p-Cl-Phe6,Leu17]-vasoactive intestinal peptide.

An increase in inhibition indicates that the drug did not reduce the relaxation, rather it increased the relaxation.