Table 1. Characteristics of CAP with severe sepsis: demographic data, comorbid conditions, radiographic and prognostic scales data.
| Characteristics | Severe Sepsis | |||
|---|---|---|---|---|
| No, n (%) | Yes, n (%) | pc | ||
| Total No. | n = 2,541 | n = 1,529 | ||
| Demographic data | Age* | 69 (50–78) | 73 (60–81) | <0.001 |
| Age ≥65 years | 1473 (58.1) | 1024 (67.1) | <0.001 | |
| Male gender | 1635 (64.3) | 1065 (69.7) | 0.001 | |
| Current smoker | 574 (22.6) | 343 (22.5) | 0.937 | |
| Alcohol abusea | 273 (10.7) | 200 (13.1) | 0.024 | |
| Prior corticosteroid treatmentb | 95 (3.8) | 74 (4.9) | 0.083 | |
| Prior antibiotic treatment | 651 (25.6) | 261 (17.1) | <0.001 | |
| Comorbid condition | Diabetes Mellitus | 566 (22.3) | 294 (19.2) | 0.020 |
| Liver disease | 102 (4) | 70 (4.6) | 0.378 | |
| Heart disease | 346 (13.6) | 227 (14.8) | 0.277 | |
| Renal disease | 136 (5.4) | 132 (8.6) | <0.001 | |
| Neurological disorders | 245 (9.7) | 157 (10.3) | 0.531 | |
| COPD | 494 (19.8) | 477 (32.0) | <0.001 | |
| Radiographic findings | Multilobar infiltrates | 501 (19.7) | 427 (27.9) | <0.001 |
| Pleural Effusion | 391 (15.4) | 248 (16.3) | 0.469 | |
| Prognostic scales | PSI (IV-V) | 866 (34.1) | 971 (63.5) | <0.001 |
| CURB65 (≥ 3) | 531 (20.9) | 663 (43.3) | <0.001 | |
Data are presented as number (percentage) unless otherwise indicated.
*Data are presented as median (interquartile range).
a Alcohol abuse: more than 80 g/day.
b Previous corticosteroid treatment: less than 20 mg ∕day prednisone or equivalent.
c p value: the χ2 test was performed for categorical data and the Mann-Whitney U test was performed for continuous data.