Table 3. Etiology of CAP in relation to severe sepsis.
| Etiology | Severe Sepsis | |||
|---|---|---|---|---|
| Groups | No, n (%) | Yes, n (%) | pa | |
| Total No. | Total No. (%) | n = 2,541 | n = 1,529 | |
| Known etiology n = 1,507 | 860 (33.8) | 646 (42.2) | <0.001 | |
| Gram-positive n = 866 | 466 (18.3) | 400 (26.2) | <0.001 | |
| S. pneumoniae n = 859 (21.1) | 463 (18.2) | 396 (25.9) | <0.001 | |
| MRSA n = 7 (0.2) | 3 (0.1) | 4 (0.3) | 0.284 | |
| Gram-negative n = 207 | 123 (4.8) | 84 (5.5) | 0.358 | |
| L. pneumophila n = 104 (2.6) | 60 (2.4) | 44 (2.9) | 0.312 | |
| H. influenza n = 43 (1.1) | 25 (1.0) | 18 (1.2) | 0.559 | |
| P. aeruginosa n = 45 (1.1) | 30 (1.2) | 15 (1.0) | 0.555 | |
| E. coli n = 15 (0.4) | 8 (0.3) | 7 (0.5) | 0.466 | |
| Atypical pathogens n = 144 | 102 (4.0) | 42 (2.7) | 0.034 | |
| C. pneumoniae n = 44 (1.1) | 26 (1) | 18 (1.2) | 0.645 | |
| C. burnetii n = 50 (1.2) | 37 (1.5) | 13 (0.9) | 0.089 | |
| M. pneumoniae n = 50 (1.2) | 39 (1.5) | 11 (0.7) | 0.022 | |
| Viruses n = 18 | 11 (0.4) | 7 (0.5) | 0.908 | |
| Mixed etiologyb n = 121 | 63 (2.5) | 58 (3.8) | 0.017 | |
| Bacteremia n = 284 | 137 (9.0) | 147 (14.5) | <0.001 | |
Data are presented as number (percentage) unless otherwise indicated.
a p value: the χ2 test was performed for categorical data.
b Mixed etiology is defined as pneumonia due to more than one pathogen (virus or bacteria).