Table 1.
Descriptive statistics of study samples included, number of cases and controls for new and published studies and OR for the GDF5 rs143383 T allele
| New data
|
Published data
|
|||||
|---|---|---|---|---|---|---|
| Rotterdam study III | Estonian knee osteoarthritis study | Hertfordshire cohort plus Nottingham cases | Genetics of osteoarthritis and lifestyle | Chingford study | Ten studies from large-scale meta-analysis (*) | |
| GDF5 association data from | This study | This study | This study | This study | 7 | 5 |
| Country of origin | Netherlands | Estonia | UK | UK | UK | Europe, China, Japan |
| Ethnicity | Caucasian | Caucasian | Caucasian | Caucasian | Caucasian | Asian and Caucasian |
| No of knee osteoarthritis cases/controls | 151/1582 | 65/427 | 1141/536 | 867/758 | 259/509 | 5085/8135 |
| Knee osteoarthritis definition | TF K/L ≥2 | TF K/L ≥2 | TF or PF K/L ≥2 or TKR | TKR | TF K/L ≥2 | Mixed |
| Women % | 56 | 69 | 52 | 49 | 100 | NA |
| BMI mean (SD) | 27.7 (4.7) | 28.1 (5.4) | 28.2 (5.1) | 29.3 (5.3) | 26.7 (4.7) | NA |
| Age mean (SD) | 56.0 (5.5) | 47.1 (6.4) | 67.2 (7.4) | 66.5 (7.9) | 64.1 (6.0) | NA |
| rs143383 T allele % in knee osteoarthritis/controls | 64.6/61.0% | 67.7/60.3% | 63.3/62.9% | 68.5/62.1% | 67.6/59.5% | NA |
| OR (95% CI) | 1.16 (0.91 to 1.49) | 1.38 (0.93 to 2.04) | 1.02 (0.87 to 1.1.8) | 1.32 (1.14 to 1.53) | 1.42 (1.13 to 1.77) | 1.15 (1.09 to 1.22) |
*
Data for all studies, the summary statistics reported for each of the individual studies were used separately and are shown in figure 1.
BMI, body mass index; K/L, Kellgren–Lawrence radiographic grade; PF, patellofemoral; TF, tibiofemoral; TKR, total knee replacement; NA, not applicable because it refers to 10 different studies.