Fig 1. R _h comparison to number of residues, N. Filled and open circles represent experimental R _h for IDPs [23,26–42] and folded proteins [22,45,46], respectively.

The solid line is the R _h dependence on N estimated from simulations of randomly configured protein structures [22]. Stippled lines show R _h for randomly configured structures with chain propensities for PP _II (f _PPII) from 0.1 to 1 in 0.1 increments. Every other stippled line is end-labeled by its f _PPII value.