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. 2015 Dec 29;10(12):e0144192. doi: 10.1371/journal.pone.0144192

Fig 4. Development of the scoring system.

Fig 4

The total score was determined by adding the scores of four different areas (S and E compartments of IF and TC regions). In addition to the total score, analysis of the compartments (S or E) and regions (IF or TC) was conducted by adding the scores of two paired areas, e.g., to determine the score of IF. We added the scores in S at IF and E at IF, which ranged from 0 to 2. For the S compartments, the scores in S at IF and S at TC were added. The same method was applied in scoring of the densities of TAMs of the other two combined areas–TC (STC + ETC) and E (EIF + ETC). Abbreviations: S, stroma; E, eithelium; IF, invasive front; TC, tumor center.