Table 3. Multivariate survival analysis of factors associated with progression-free survival.
| Multivariate analysis—II | Multivariate analysis—III | Multivariate analysis—IV | ||||
|---|---|---|---|---|---|---|
| Parameters | Hazard ratio | P value | Hazard ratio | P value | Hazard ratio | P value |
| (month;95% confidence interval) | (month;95% confidence interval) | (month;95% confidence interval) | ||||
| AJCC stage | <0.001 | <0.001 | <0.001 | |||
| I/II | Reference | Reference | Reference | |||
| III | 6.112 (2.340–15.966) | 5.410 (2.185–13.395) | 6.634 (2.513–17.513) | |||
| Ming classification | 0.065 | 0.059 | 0.042 | |||
| Expanding | Reference | Reference | Reference | |||
| Infiltrative | 6.677 (0.886–20.290) | 7.003 (0.928–52.818) | 8.097 (1.078–60.786) | |||
| Lymphatic invasion | 0.316 | 0.449 | 0.585 | |||
| Absent | Reference | Reference | Reference | |||
| Present | 1.770 (0.580–53.401) | 1.483 (0.535–4.111) | 1.395 (0.423–4.597) | |||
| Vascular invasion | 0.105 | 0.085 | 0.179 | |||
| Absent | Reference | Reference | Reference | |||
| Present | 2.256 (0.844–6.030) | 2.340 (0.890–6.150) | 1.967 (0.733–5.279) | |||
| Perineural invasion | 0.850 | 0.993 | 0.657 | |||
| Absent | Reference | Reference | Reference | |||
| Present | 1.083 (0.474–2.477) | 1.003 (0.443–2.274) | 1.207 (0.526–2.768) | |||
| CD163+ TAM density–IF(SIF+EIF) | 0.051 | Not included* | Not included* | |||
| Low (score 0) | Reference | |||||
| High (score 1,2) | 0.458 (0.209–1.004) | |||||
| CD163+ TAM density–S(SIF+STC) | Not included* | 0.028 | Not included* | |||
| Low (score 0) | Reference | |||||
| High (score 1,2) | 0.413 (0.188–0.910) | |||||
| CD163+ TAM density–E(EIF+ETC) | Not included* | Not included* | 0.048 | |||
| Low (score 0) | Reference | |||||
| High (score 1,2) | 0.428 (0.185–0.991) | |||||
* Because the covariate associated with CD163+ tumor associated macrophage density–IF (SIF+EIF), S (SIF+STC) and E (EIF+ETC)–are positively associated with each other, they could not be included in multivariate analysis at the same time. Therefore, these parameters were added to each set of multivariate analysis one by one.
TAM, tumor associated macrophage; SIF, stromal tumor associated macrophage density in invasive front; STC, stromal tumor associated macrophage density in tumor center; EIF, epithelial tumor associated macrophage density in invasive front; ETC, epithelial tumor associated macrophage density in tumor center; IF, invasive front; E, epithelium; S, stroma; BMI, body mass index.