Table 3.
Area under the curve (AUC), odds ratios, and positive and negative predictive values predicting Aβ status from biomarkers.
AUC | Odds Ratio |
PPV | NPV | ||
---|---|---|---|---|---|
Mini-Mental Status Examination | 0.61±0.03 | 1.94±0.60 | 0.71±0.05 | 0.43±0.05 | |
AVLT Trial 5 Recall | 0.65±0.03 | 3.01±0.36 | 0.75±0.04 | 0.50±0.05 | |
AVLT 5-min Recall | 0.65±0.02 | 2.50±0.44 | 0.73±0.05 | 0.47±0.04 | |
AVLT 30-min Recall | 0.67±0.02 | 2.46±0.52 | 0.73±0.05 | 0.48±0.06 | |
AVLT Recognition Discrimination | 0.64±0.03 | 2.44±0.55 | 0.73±0.02 | 0.48±0.07 | |
Retention | 0.67±0.03 | 2.48±0.48 | 0.73±0.03 | 0.47±0.06 | |
Trail Making Test A | 0.62±0.02 | 2.13±0.46 | 0.73±0.04 | 0.44±0.05 | |
Trail Making Test B | 0.63±0.02 | 2.49±0.48 | 0.75±0.05 | 0.45±0.05 | |
Boston Naming Test | 0.59±0.02 | 1.66±0.17 | 0.70±0.03 | 0.42±0.04 | |
Category fluency (animals) | 0.60±0.02 | 1.88±0.43 | 0.71±0.05 | 0.42±0.03 | |
Hippocampal volume | 0.64±0.02 | 2.41±0.34 | 0.74±0.04 | 0.46±0.04 | |
Medial Temporal Thickness | 0.59±0.01 | 1.67±0.07 | 0.70±0.04 | 0.42±0.04 | |
Precuneal Thickness | 0.59±0.02 | 1.83±0.25 | 0.71±0.03 | 0.43±0.05 | |
Mean Cortical Thickness of AD Meta-ROI | 0.61±0.02 | 1.90±0.31 | 0.71±0.04 | 0.43±0.04 | |
Mean FDG-PET SUVR of AD Meta-ROI | 0.67±0.03 | 3.19±1.22 | 0.76±0.05 | 0.49±0.08 | |
Principal component analysis of psychometric scores | 0.68±0.02 | 3.38±1.16 | 0.71±0.03 | 0.56±0.10 | |
Principcal component analysis of psychometric scores and imaging biomarkers | 0.69±0.02 | 3.18±0.76 | 0.71±0.03 | 0.55±0.08 | |
Principal component analysis of cortex-wide cortical thickness | 0.59±0.03 | 1.57±0.21 | 0.67±0.04 | 0.43±0.02 |