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. 2015 Dec 29;10(12):e0145512. doi: 10.1371/journal.pone.0145512

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© 2015 Thomas et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — A. Size measurement by DLS and surface charge measurement by zeta potential of HA micelle and losartan-HA micelle in PBS at 7.4 pH. HA micelle and losartan-HA micelle was taken at 100 μg/ml concentration and bath sonicated (Power Sonic410,Hwashin,Korea) for 5 minutes at room temperature and measured; B. TEM image of a SPION loaded HA micelle and SEM image of losartan-HA micelle (inset). The size of losartan-HA micelle was estimated to be around 300nm based on SEM and DLS result whereas the morphology of particle was confirmed from TEM and SEM image.