Figure 1.

Structure and Conservation of the NEC

(A) The pUL31-pUL34 complex in cartoon representation. pUL31 is shown in orange, and pUL34 is shown in gray. Unresolved regions are indicated by dashed lines, and the pUL31 bound Zn²⁺ ion is indicated in blue. Secondary structure elements are labeled on the structure (see also Figure S2). The inner nuclear membrane (yellow) and the transmembrane region of pUL34 (green) are schematically drawn.

(B) pUL31 structure colored according to the previously described conserved regions CR1–CR4 (Lötzerich et al., 2006). CR1, dark green; CR2, light green; CR3, yellow; CR4, orange. The Zn²⁺ ion and its complexing residues, shown in stick representation, are indicated.

(C) Mapping of the sequence conservation for pUL31 (see sequence alignment in Figure S2A), ranging from dark red for the most conserved to light gray for the least conserved residues.

(D) Mapping of the sequence conservation for pUL34 (see sequence alignment in Figure S2B). Color code is as in (C).

See also Figure S2.