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. 2015 Dec 17;13(12):2768–2780. doi: 10.1016/j.celrep.2015.12.002

Figure 3.

Figure 3

Lower Efficacy of GABA Synapses after Reduced IICR Activity

(A) Examples show GABAergic mIPSC traces recorded in cultured hippocampal neurons in the absence (left) or presence (right) of mGluR inhibitor MCPG.

(B) Distribution of mIPSC amplitudes in the absence (white, top and bottom) or presence (gray, middle and bottom) of MCPG. Note that the distribution of mIPSC amplitudes is shifted toward lower values in MCPG-treated neurons.

(C and D) Cumulative distributions of time to peak (C) and decay time constant (D) of mIPSCs in the absence (open) or presence of MCPG (close). The first 15 events were collected from seven neurons per condition.

(E) Distributions of mIPSC amplitudes recorded in pyramidal neurons from P14–P16 WT (white, top and bottom) or IP3R1KO mice (gray, middle and bottom) hippocampal slices. The overlay emphasizes the reduction in mIPSC amplitudes in IP3R1KO.

(F and G) Distributions of time to peak (F) and decay time constant (G) of mIPSCs of WT (white circle) and IP3R1KO (black circle). The first 250 events were collected from four neurons per condition (∗∗∗p < 0.005; ns, not significant; Mann-Whitney U-test).