. 2015 Oct 7;61:25–38. doi: 10.1007/s10620-015-3884-5

Table 3.

Meta-analyzed markers assessed in association with BE susceptibility

Marker			Individual study			Meta-analysis
Marker			Association			Meta-analysis
Variant	Gene	EV	Variant	Wild-type	No association	OR (95 % CI)	I ²	Chi	p	n
Null	GSTM1	Null	Null		Kadioglu et al. [55]	BE 0.83 (0.61–1.12)	27 %	4.12	0.220	4
					Kala et al. [19]	BE^{no IM} 0.66 (0.44–0.99)	0 %	0.64	0.420	2
					Casson et al. [46]	BE^IM 1.12 (0.70–1.80)	0 %	0.64	0.630	2
					van Lieshout et al. [56]
rs4880	SOD2	T	T		Kadioglu et al. [55], di Martino et al. [49]	BE^IM 0.90 (0.65–1.24)	0.00	0.07	0.520	3
					Murphy et al. [45]
rs16944	IL1B	AA	AA		Izakovicova-Holla et al. [27], Gough et al. [28]	BE 1.13 (0.63–2.03)	0.00	0.00	0.680	2
rs1052133	OGG1	G	G		Kadioglu et al. [55], Ferguson et al. [49]	BE^{A IM} 1.34 (0.59–3.09)	67 %	3.01	0.480	2
rs25487	XRCC1	TT	TT	Casson et al. [48]	Ferguson et al. [49]	BE^{A IM} 0.65 (0.25–1.68)	71 %	3.42	0.370	2
rs13181	ERCC2	CC	CC		Casson et al. [48], Fergusons et al. [49]	BE^{A IM} 0.92 (0.57–1.48)	31 %	1.44	0.730	2

EV effect variant, OR odds ratio, CI confidence interval, IM intestinal metaplasia, BE Barrett’s esophagus