. 2015 Oct 7;61:25–38. doi: 10.1007/s10620-015-3884-5

Table 5.

Reported somatic biomarkers of Barrett’s esophagus progression to dysplasia/adenocarcinoma following photodynamic therapy

Marker			Individual study							Association (meta-analysis/individual study)
LOE	Variant	Gene	Association		EV	LOE	Ethnicity	Phenotype	Adjusted for confounders?	Association (meta-analysis/individual study)
LOE	Variant	Gene	Variant	None	EV	LOE	Ethnicity	Phenotype	Adjusted for confounders?	Phenotype HR (95 % CI)	I ²	Chi	p	n
IV	CIN	NA	Dunn et al. [65]		CIN 4 m post-PDT	D	NS	HGD	Yes	EAC/HGD HR^A 4.10 (1.30–13.0)	NA	NA	9.00 × 10⁻³	1
IV	CIN	NA	Dunn et al. [65]		CIN 12 m post-PDT	D	NS	HGD	Yes	EAC/HGD HR^A 3.60 (1.05–12.3)	NA	NA	2.90 × 10⁻³	1

LOE level of evidence, CIN chromosomal instability, EV effect variant, HR hazard ratio, CI confidence interval, PDT photodynamic therapy, HGD high-grade dysplasia, EAC esophageal adenocarcinoma