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. 2015 Nov 18;95:11–18. doi: 10.1007/s00277-015-2553-2

Table 3.

CT and FDG-PET acquisition/interpretation and patient follow-up methods

Study (year) Histological grade FDG-PET imaging system(s) FDG dose Time between FDG administration and scanning Time between last therapy cycle and FDG-PET (range) Interpreters Baseline scan available (no.) Follow-up examinations to determine end of PFS Definition of end of PFS
Lu et al. [6] (2014) 1-3A Stand-alone PET (n = 15) or hybrid PET/CT (n = 42) 5.14 MBq/kg 60 min NR Experienced PET physicians Yes (55/57 cases) NR Relapse or aggressive transformation
Luminari et al. [7] (2014) NR Hybrid PET/CT NR NR 36 daysa (10–92) Local nuclear medicine physician scan report Yes (155/202 cases) NR Progression, relapse, or death from any cause
Zinzani et al. [8] (2013) Grade 1-3A NR NR NR NR Local nuclear medicine physician scan report Yes CT every 6 months for the first 2 years, annual imaging studies with CT or FDG-PET/CT up to 7 years Progression or death from any cause
Dupuis et al. [9] (2012) 1-3A NR 3.5–8 MBq/kg 60 min NR Central review by 3 experienced nuclear medicine physicians Yes (all) Clinical examination every 3 months and CT scan every 6 months during the first 2 years First documented evidence of progressive disease, relapse, or death resulting from any cause
Trotman et al. [10] (2011) NR Hybrid PET/CT NR NR 64 daysa (9–124) Local nuclear medicine physician scan report NR Clinical examination every 3 months and CT scans every 6 months for 3 years Progression/relapse (on the basis of the investigator's assessment) or death from any cause
Le Dortz et al. [11] (2010) 1-3a Hybrid PET/CT 5 MBq/kg 60 min NR Two nuclear medicine specialists Yes (all) NR Progression, relapse or second-line therapy
Bishu et al. [12] (2007) 1 or 2 Stand-alone PET or hybrid PET/CT 370–740 MBq 60 min NR Experienced nuclear radiologists Yes (all) Conventional methods every 3–6 months for 1 year, every 6–12 months for 2 years, FDG-PET examination every 3–12 months Histologic, clinical or radiographic evidence of disease progression
Zinzani et al. [13] (2007) 1 or 2 Stand-alone PET 370 MBq 70–90 min Approximately 30 days Three experienced readers Yes CT and FDG-PET were performed every 6 months for the first 2 years and then every 12 months Progression or relapse

NR not reported, PFS progression-free survival

aMedian