Table 2.
Gene expression changes
| Gene | Genotype | Treatment | Relative expression | Sem |
|---|---|---|---|---|
| IP-10 | Control | Control | 1.00 | 0.35 |
| Control | Mithramycin | 0.24 | 0.03 | |
| Transgenic | Control | 2.42 | 1.31 | |
| Transgenic | Mithramycin | 0.88 | 0.10 | |
| p53 | Control | Control | 1.00 | 0.13 |
| Control | Mithramycin | 0.42 | 0.05 | |
| Transgenic | Control | 2.08 | 0.94 | |
| Transgenic | Mithramycin | 0.64 | 0.21 | |
| Bcl-2 | Control | Control | 1.00 | 0.06 |
| Control | Mithramycin | 0.70 | 0.09 | |
| Transgenic | Control | 1.80 | 0.24 | |
| Transgenic | Mithramycin | 1.40 | 0.16 |
mRNA levels in the hippocampus were examined for IP-10, p53, andbcl-2 by qRT-PCR, normalized to 18S rRNA, and are depicted relative to the untreated, non-transgenic mice. Significant differences were not detected.