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. 2016 Jan 5;6:1479. doi: 10.3389/fmicb.2015.01479

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Copyright © 2016 Park, Mulelu, Sewell and Benedik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between the region 1 and region 2 insertions and the C-surface based on crystal structures of two spiral forming members of the nitrilase superfamily (A) β-alanine synthase from Drosophila melanogaster (PDB id: 2VHI) and (B) the oxy-nitrilase from Synechocystis sp. PCC6803 (PDB id: 3WUY). Region 1 is highlighted in red and region 2 is highlighed in green. In both cases there is a further contributor to the interface depicted in blue. This sequence contains a glutamate (depicted in pink) that is hydrogen bonded to the lysine of the putative catalytic triad comprising a cysteine (yellow), a glutamate (pink), and the lysine (purple).