Skip to main content
. 2016 Jan 5;6:18830. doi: 10.1038/srep18830

Table 1. Methods of scoring system and criteria for determining ER/PR and Her2/Neu positivity and negativity.

The ER/PR scoring methods and criteria
Scoring methods
 0 Negative for ER/PR receptors
 1 Barely detected
 2+/3+ Positive for ER/PR receptors
Criteria
 0 No or 0% nuclear staining
 1+ <15% or occasional nuclear staining (1–15%)
 2+ >15% to 75% clear positive nuclear staining
 3+ >75% positive staining
Her2/Neu scoring method and criteria
 0 Negative.
 1+ Negative/very weakly positive.
 2+ Weakly sporadic positive
 3+ Positive
Criteria
 0 0% or no staining was observed, negative staining.
 1+ Barely/very faint membranous staining but the staining did not reach more than 10%.
 2+ The staining intensity was weak, occasional membranous staining was observed, total positive staining tumor cells higher than 10%.
 3+ Strong consistent positive membranous staining in more than 10% of tumor cells.