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. 2016 Jan 5;6:18751. doi: 10.1038/srep18751

Figure 3. PDK4 mediates metabolic reprogramming induced by FXR activation.

Figure 3

(A) Expression of major enzymes in the glycolysis pathway in HepG2 cells after treatment with GW4064. (B) Expression of major enzymes in the glycolysis pathway in HepG2 cells after treatment with CDCA. (C) Expression of major enzymes in the glycolysis pathway in HepG2 cells after treatment with 10 μM GS combined with 5 μM GW4064. (D) Expression of major enzymes in the glycolysis pathway in HepG2 cells after transfection with FXR siRNA. (E) Expression of major enzymes in the glycolysis pathway in HepG2 cells transfected with FXR siRNA with or without GW4064 treatment. Values are presented with mean ± SD (n = 6; *P < 0.05; **P < 0.01; ***P < 0.001).