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. 2016 Jan 5;6:18751. doi: 10.1038/srep18751

Figure 6. Activation of FXR advances liver regeneration associated with glycolytic reprogramming.

Figure 6

Mice were pretreated with vehicle (Veh) or GW4064 (GW) for 3 days and subsequently challenged with 300 mg/kg APAP. (A) Serum ALT and AST activity measured at 4 hours and 24 hours after APAP treatment of mice. (B) Representative photomicrographs of H&E-stained liver sections and photomicrographs of PCNA IHC staining of liver sections of APAP-treated mice. Original magnification, ×200. (C) Concentrations of major intermediates in glycolysis pathway in liver and plasma obtained at 4 hours and 24 hours after APAP treatment. (D) Gene expression of FXR target genes, Pdk4, Pdhx and Phgdh in liver. Values are presented with mean ± SD (n = 6; *P < 0.05; **P < 0.01).