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. 2016 Jan 4;212(1):91–111. doi: 10.1083/jcb.201506018

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© 2016 Fusco et al.

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Figure 3. — Identification of a candidate Rho GTPase signaling network. (a) Rho GTPase protein interaction network as determined by the strategy described in Materials and methods. Different families of proteins known to interact with six expressed Rho GTPases are shown. Proteins are named by their official gene symbol according to Entrez Gene. Relative neurite protein enrichment is color-coded according to the color scale bar at the bottom of the figure. Plain lines represent direct protein–protein interaction. Icons are color-coded according to the color scale bar. (b) Gene Ontology analysis of the most significant canonical pathways present in the protein network shown in panel a. Dotted line represents significance threshold as measured by Fisher’s exact test (P < 0.05).