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. 2016 Jan 4;212(1):91–111. doi: 10.1083/jcb.201506018

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© 2016 Fusco et al.

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Figure 7. — Temporal analysis of neuronal dynamics in control and MKK7-KD cells. (a–d) Control and MKK7-KD time-lapse sequences from multiple experimental plates were divided in 19 1-h bins. Coefficient of variation of selected features for each temporal bin for control (a and c) and MKK7 KD (b and d) cells. Measurements for the whole-cell population (a and b) and the 10% of cells with the highest neurite extreme length (c and d) are shown. Representative HDS graph representations of cells from the tenth percentile at the 1-, 5-, 10-, 15-, and 20-h time points have been identified using a mathematical model (Materials and methods; c and d). (e) Feature distributions at the two different time point intervals (1–6 h and 14–20 h). Vertical bars display distribution means.