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. 2016 Jan 4;212(1):113–124. doi: 10.1083/jcb.201506055

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© 2016 Enemchukwu et al.

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Figure 3. — Lumen formation for epithelial cysts within PEG-4MAL hydrogels involves cell apoptosis. (A) Transmitted light and fluorescence microscopy images of MDCK cells cultured within PEG-4MAL hydrogels. Samples were stained for filamentous actin and caspase-3. (B) Distribution of cysts staining positive for caspase-3 (>103 cysts analyzed per condition). χ² test with Bonferroni’s correction *, P < 0.005, 3.5% versus 4.5% and collagen. (C) Epithelial cyst size (median shown as red line) as a function of PEG-4MAL hydrogel polymer density (>62 cysts analyzed per condition). χ² test with Bonferroni’s correction. Day 2: *, P < 0.05, 5.0% versus all other polymer densities; **, P < 0.01, 5.0% versus collagen. Day 5: *, P < 0.05, 4.5% versus collagen. Day 10: *, P < 0.05, collagen versus PEG-4MAL groups.