Figure 2. Female DISC1^D453G mice show hyperlocomotion and thigmotaxis in the open field.

Wild-type (+/+; n = 17, 10 male and 7 female) and DISC1^D453G (D453G/D453G; n = 17, 7 male and 10 female) mice were allowed 30 min for free exploration of the arena. (A) Female DISC1^D453G mice consistently travelled further than female wild-type littermates over the 30 min test period, showing a significant genotypic difference in total distance travelled. (B) The distance travelled was not significantly different between male wild-type and DISC1^D453G mice. When the arena was broken into outer, intermediate and center zones, female DISC1^D453G mice spent significantly more time in the outer zone (C), and significantly less time in the center zone (D). There were no genotypic differences among males. * P < 0.05, **P < 0.01, ***P < 0.001 vs. female +/+.