Figure 3. Female DISC1^D453G mice exhibit an anxiogenic profile in the elevated plus-maze.

(A) Female DISC1^D453G mice (D453G; n = 10) spent significantly less time than female wild-type littermates (+/+; n = 7) exploring the open arms. There were no genotypic differences among males (P > 0.05). (B) Female DISC1^D453G mice spent significantly more time in the closed arms than female wild-types, whereas male DISC1^D453G mice showed a non-significant trend for spending less time in the closed arms (P = 0.063). (C) The center of the elevated plus-maze is where the open and close arms intersect. Male DISC1^D453G mice spent significantly more time at the center compared with wild-type males. Female DISC1^D453G mice spent significantly less time at the center compared with wild-type females. (D) Head dips made on the open arms are indicative of exploratory behavior. Female DISC1^D453G mice made significantly fewer head dips compared with wild-type females. *P < 0.05, **P < 0.01 versus +/+ of the same sex.