Figure 4. Female DISC1^D453G mice show less social interaction.

(A) Time spent by wild-type (+/+; n = 16, 9 male and 7 female) and DISC1^D453G (D453G; n = 17, 7 male and 10 female) mice exploring a novel mouse or an empty container. All groups were able to discriminate between a novel mouse (Stranger 1) and an empty container, but female DISC1^D453G mice spent significantly less time than wild-type females interacting with the novel mouse. There was no genotypic difference in time in contact with the novel mouse among males (P > 0.05). (B) The mice were then tasked with discriminating between the mouse previously explored and a second novel adult male mouse (Stranger 2). Again, both genotypes and sexes were able to correctly discriminate the second novel mouse, but female DISC1^D453G mice spent significantly less time interacting with the novel male mouse. There were no male genotypic differences (P > 0.05). *P < 0.05, **P < 0.01 vs. female +/+.