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. 2016 Jan 5;6:18748. doi: 10.1038/srep18748

Figure 5. DISC1D453G affects long-term memory of male mice in the passive avoidance test but has no effect on PPI.

Figure 5

(A) The percentage of PPI at four different tones was measured. DISC1D453G mice (D453G/D453G; n = 17, 7 male and 10 female) showed similar PPI to wild-types (+/+; n = 17, 10 male and 7 female), with no significant differences (P > 0.05). (B) Long-term (24 hr) memory was assayed using the passive avoidance test, whereby the mouse must learn to suppress its innate preference for the dark chamber through footshock conditioning. Initially, mice readily cross to the dark chamber (left side, Conditioning). 24 hr later, the latency to cross was measured again (right side, Test). Compared with wild-type mice, DISC1D453G mice more readily crossed to the chamber in which the footshock was delivered. There were no genotypic differences among females (P > 0.05). *P < 0.05 vs. male +/+.