Table 1. Summary of observed phenotypes of DISC1D453G mutant mice.
| Phenotype | Male DISC1D453G | Female DISC1D453G |
|---|---|---|
| Open Field | ||
| Distance travelled (m) | = | ↑ |
| Time spent in outer zone | = | ↑ |
| Time spent in center zone | = | ↓ |
| Rearing (s) | ↓ | = |
| Elevated Plus-Maze | ||
| Time spent in open arms (%) | = | ↓ |
| Open arm entries | = | ↓ |
| Time spent in closed arms (%) | = | ↑ |
| Time spent in center (%) | ↑ | = |
| Head dips | = | ↓ |
| Social Interaction | ||
| Novel mouse vs. empty container | = | ↓ |
| Stranger 2 vs. Stranger 1 | = | ↓ |
| Passive Avoidance | ||
| Latency to cross (24 hours) | ↓ | = |
| DISC1-GSK3β pathway | ||
| DISC1 protein level | = | = |
| DISC1-GSK3β binding | ↓ | ↓ |
| GSK3β protein level | = | = |
| Phospho-inhibition of GSK3β | ↓ | ↓ |
| β-catenin protein level | ↓ | ↓ |
= no significant difference, ↓ decreased, ↑ increased; versus wild-type of the same sex.