TABLE 2.
GABBR1 rs29220 genotype frequencies in the three study samples
| Sample | GABBR1 rs29220 genotypes | N | MAF | HWE | ||
|---|---|---|---|---|---|---|
| CC | GC | GG | p value | |||
| AA men, any addiction | 166 (0.41) | 189 (0.47) | 46 (0.12) | 401 | 0.35 | 0.48 |
| AA men, total AUD | 105 (0.41) | 117 (0.46) | 32 (0.13) | 254 | 0.36 | 0.95 |
| AA men, controls | 95 (0.49) | 62 (0.32) | 36 (0.19) | 193 | 0.35 | 0.0001 |
| AA women, controls | 110 (0.40) | 115 (0.42) | 52 (0.18) | 277 | 0.39 | 0.03 |
| Finns, all AUD | 47 (0.30) | 89 (0.56) | 23 (0.14) | 159 | 0.43 | 0.09 |
| Finns, AUD + ASPD | 24 (0.26) | 58 (0.62) | 11 (0.12) | 93 | 0.44 | 0.01 |
| Finns, controls | 68 (0.38) | 73 (0.40) | 40 (0.22) | 181 | 0.42 | 0.03 |
| PI all AUD | 112 (0.47) | 95 (0.40) | 32 (0.13) | 239 | 0.33 | 0.11 |
| PI controls | 52 (0.29) | 94 (0.53) | 32 (0.18) | 178 | 0.44 | 0.35 |
N (frequency) for each genotype; MAF = minor allele frequency; HWE = Hardy-Weinberg Equilibrium AA = African Americans; Finns = Finnish Caucasians; PI = Plains American Indians AUD = alcohol use disorders (for AA men this includes single and comorbid diagnoses); ASPD = antisocial personality disorder