Table 1.
Proteins analyzed | IHC score, n | Overexpressed, n (%) | |||
---|---|---|---|---|---|
3+ | 2+ | 1+ | 0 | ||
SHP2 | 22 | 17 | 11 | 6 | 39 (70 %) |
EGFR | 13 | 20 | 9 | 5 | 33 (59 %) |
EGFR epidermal growth factor receptor, IHC immunohistochemistry, SHP2 Src homology phosphotyrosyl phosphatase 2
A total of 56 basal-like and triple-negative breast cancer tumor samples were analyzed for SHP2 and EGFR by immunohistochemistry as described in Materials and methods. Samples that showed 3+ and 2+ expression levels were considered as positive for elevated expression of SHP2 and EGFR