Figure 1. Experimental design.

The study design entailed 5 different exposure groups, 6 necropsy time points, and 5 main endpoint categories, where mice were allocated for each category. The number of mice planned in the study per exposure group for each endpoint and time point and the design are summarized in (a). To ascertain the best quality of the data to answer the scientific questions, a number of quality control and randomization steps were put in place (b).