Table 3.

Unadjusted Association of Cumulative Exposure to Overall, Normal, and Elevated Cardiovascular Risk Factors and Cognitive Function at Midlife Among 3381 CARDIA Participants

	Standardized Difference (95% CI)
	Rey Auditory Verbal Learning–Delayed*	Digit Symbol Substitution Test*	Stroop Interference*
Systolic blood pressure
Overall	−0.14 (−0.17 to −0.10)†	−0.21 (−0.24 to −0.18)†	−0.13 (−0.16 to −0.10)†
Normal levels	−0.07 (−0.11 to −0.03)†	−0.15 (−0.19 to −0.11)†	−0.06 (−0.10 to −0.02)‡
Elevated levels	−0.74 (−0.92 to −0.57)†	−0.77 (−0.94 to −0.59)†	−0.73 (−0.91 to −0.55)†
Diastolic blood pressure
Overall	−0.12 (−0.16 to −0.09)†	−0.19 (−0.22 to −0.16)†	−0.13 (−0.16 to −0.09)†
Normal levels	−0.07 (−0.11 to −0.03))†	−0.15 (−0.19 to −0.11)†	−0.08 (−0.12 to −0.04)†
Elevated levels	−0.78 (−1.01 to −0.55)†	−0.71 (−0.94 to −0.47)†	−0.75 (−0.98 to −0.51)†
Fasting blood glucose
Overall	−0.09 (−0.13 to −0.06)†	−0.16 (−0.19 to −0.12)†	−0.09 (−0.13 to −0.06)†
Normal levels	−0.05 (−0.09 to .00)§	−0.13 (−0.18 to −0.09)†	−0.04 (−0.09 to 0.01)
Elevated levels	−0.19 (−0.26 to −0.12)†	−0.21 (−0.28 to −0.14)†	−0.20 (−0.27 to −0.13)†
Total cholesterol
Overall	−0.03 (−0.06 to 0.01)	−0.05 (−0.09 to −0.02)‡	−0.03 (−0.07 to 0.00)
Normal levels	−0.02 (−0.03 to 0.06)	−0.05 (−0.09 to 0.00)§	−0.03 (−0.08 to 0.01)
Elevated levels	−0.11 (−0.16 to −0.05)†	−0.06 (−0.12 to −0.01)§	−0.04 (−0.09 to 0.02)

CARDIA indicates Coronary Artery Risk Development in Young Adults; and CI, confidence interval.

^*Per 1-SD increase in area under the curve.

^†P<0.001.

^‡P<0.01.

^§P<0.05.