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. Author manuscript; available in PMC: 2016 Jan 5.
Published in final edited form as: Nature. 2015 Jun 18;522(7556):315–320. doi: 10.1038/nature14451

Extended Data Figure 2. In vitro Activity.

Extended Data Figure 2

a. In vitro activity against a panel of resistant and sensitive strains of P. falciparum. Abbreviations: chloroquine (CQ), pyrimethamine (PYR), cycloguanil (CYC), quinine (QUI), sulfadoxine (SUL) and/or mefloquine (MFQ). Resistance as follows: K1 (CQ, SUL, PYR, CYC); W2 (CQ, SUL, PYR, CYC); 7G8 (CQ, PYR, CYC); TM90C2A (CQ, PYR, MFQ, CYC); D6 (MFQ); V1/S (CQ, SUL, PYR, CYC). Data are the means ± s.d. of n=3 independent [3H]hypoxanthine incorporation experiments (each run in duplicate). b. Ex-vivo activity against P. falciparum and P. vivax clinical isolates from Papua (Indonesia). c. Effect of DDD107498 on P. falciparum 3D7, HepG2 and MRC5 cells. Data are the means ± s.d. of n reported independent experiments.