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. 2015 Nov 5;37(1):39–48. doi: 10.1093/carcin/bgv156

Figure 5.

Figure 5.

Deletion of Mdr2 increases intestinal tumor incidence. (A–H) Histological analysis of untreated and AOM/DSS treated intestines in WT and Mdr2 −/− mice. (I) Total number of intestinal polyps was counted in 12 WT and 12 Mdr2 −/− mice after AOM/DSS treatment. Compared to WT littermates, significant increase in poly number was observed in Mdr2 −/− mice. ***P < 0.0005, Student’s test. (J) Mdr2 deficiency enhances tumor growth. The percentage of total number of polyps in 12 WT and 12 Mdr2 −/− mice with size inferior to 2mm, between 2 and 5mm and superior to 5mm is presented.