Table 2. Descriptive analysis and comparisons of hemostasis parameters between pretreatment Group 1 (N = 56) and Group 2 (N = 43).

VARIABLE		Group 1 Median (IQR) [n]	Group 2 Median (IQR) [n]	P Value a	Normal range (units)
D-dimer		228.5 (119.0) [56]	201.0 (125.0) [43]	0.0262	50–400 (μg/L)
Prothrombin fragment 1+2		1.8 (1.3) [56]	0.8 (0.4) [43]	< 0.0001	0.40–1.1 (nM)
PAI-1		24.6 (14.5) [56]	21.3 (14.5) [43]	0.0680	4.0–43.0 (ng/mL)
Factor VIIa		3.5 (1.4) [56]	2.9 (1.8) [43]	0.4312	1.5–4.1 (ng/mL)
PAP complexes		360.9 (275.8) [56]	258.1 (225.8) [43]	0.0006	80–470 (μg/L)
P-selectin		41.8 (40.0) [56]	32.1 (21.7) [43]	0.0200	3–90 (μg/mL)
ETP		475.2 (99.2) [56]	412.4 (75.8) [43]	<0.0001	351–473 (mEq)
Prothrombin time		98.5 (5.0) [56]	98.0 (5.0) [43]	0.4701	0.85–1.15 (ratio)/ 80–100 (%)
Attp		30.0 (3.0) [56]	30.0 (4.0) [43]	0.4849	25–35 (sec)
Fibrinogen		3.5 (0.8) [56]	3.4 (0.8) [43]	0.8540	1.5–4.5 (g/L)
Antithrombin		104.5 (16.5) [56]	101.0 (18.0) [43]	0.4518	60–140 (%)
Plasminogen		108.5 (17.5) [56]	107.0 (16.0) [43]	0.1467	60–140 (%)
Protein C		103.0 (30.5) [56]	104.0 (27.0) [43]	0.7082	60–140 (%)
Total protein S		87.0 (14.5) [56]	88.0 (12.0) [43]	0.8156	60–140 (%)
Free protein S		85.5 (11.5) [56]	88.0 (13.0) [43]	0.1125	60–140 (%)
FVIII		112.5 (51.0) [56]	103.0 (36.0) [43]	0.1391	60–140 (%)
FvWAg		136.0 (52.0) [56]	116.0 (46.0) [43]	0.0758	65–150 (U/dL)
Microparticles		21.1 (11.0) [56]	17.7 (13.5) [43]	0.0112	8–30 (nM)
CD40L		98.2 (39.3) [56]	89.0 (42.1) [43]	0.6952	30–145 (pg/mL)
Tissue factor		116.5 (50.1) [56]	124.2 (57.3) [43]	0.3737	80–280 (ng/mL)
ADAMT13		103.8 (41.9) [56]	97.9 (60.1) [43]	0.8905	50–120 (ng/mL)
Factor XIIa		3.7 (3.9) [56]	3.1 (4.6) [43]	0.3178	1.0–4.4 (ng/mL)
Factor V Leiden b	No mutation	55 (98%)	42 (98%)	1.0000 c	Mutations/no mutations
	Heterocygote	1 (2%)	1 (2%)
G20210Ab	No mutation	56 (100%)	43 (100%)		Mutations/no mutations

^a Wilcoxon rank sum test P value

^b Absolute frequency (column percentage)

^c Fisher’s exact test