TABLE 3.

Concentrations of plasma obesity-associated hormones and serum insulin and glucose in overweight or obese postmenopausal MGTT participants given GTE or placebo for 12 mo¹

Variable	GTE (n = 117)	Placebo (n = 120)	P value
Insulin, μIU/mL
Baseline	6.65 (6.05, 7.31)	6.24 (5.68, 6.85)	0.33
Month 12	6.96 (6.33, 7.65)	6.63 (6.03, 7.28)	0.46
Change from baseline	0.31 (−0.17, 0.78)	0.29 (−0.18, 0.77)	0.97
Glucose, mg/dL
Baseline	97.6 (95.3, 100.0)	97.3 (95.0, 99.7)	0.84
Month 12	95.3 (93.0, 97.6)	94.7 (92.5, 97.0)	0.74
Change from baseline	−1.60 (−3.2, 0.007)	−1.97 (−3.58, −0.36)	0.74
HOMA-IR
Baseline	1.60 (1.45, 1.78)	1.50 (1.35, 1.66)	0.35
Month 12	1.64 (1.48, 1.82)	1.55 (1.40, 1.72)	0.45
Change from baseline	0.07 (−0.06, 0.19)	0.05 (−0.08, 0.18)	0.85
Adiponectin, μg/mL
Baseline	6.37 (5.68, 7.15)	6.80 (6.06, 7.63)	0.42
Month 12	6.62 (5.90, 7.43)	6.62 (5.90, 7.44)	0.99
Change from baseline	0.72 (0.14, 1.29)	0.11 (−0.48, 0.69)	0.14
Ghrelin, pg/mL
Baseline	1130 (1020, 1250)	1100 (991, 1210)	0.65
Month 12	1130 (1020, 1250)	1150 (1040, 1270)	0.82
Change from baseline	13.4 (−50.9, 77.6)	57.9 (−6.98, 122.7)	0.32
Leptin, μg/L
Baseline	31.6 (28.2, 35.5)	29.9 (26.6, 33.6)	0.49
Month 12	30.7 (27.4, 34.5)	30.0 (26.4, 33.2)	0.64
Change from baseline	0.65 (−1.79, 3.10)	−1.14 (−3.63, 1.34)	0.30

¹Baseline and month 12 data are presented as geometric means (95% CIs). Changes from baseline are presented as arithmetic means (95% CIs), adjusted for changes in BMI, baseline value, and COMT genotype. COMT, catechol-O-methyltransferase; GTE, green tea extract; MGTT, Minnesota Green Tea Trial.