Table 3. Histopathological findings in Dahl/ss rats deceased before study termination.

Incidence of non-neoplastic lesions by average grading per organs affected is shown. Necropsy status: terminal sacrifice group, deaths only. Grade 1–5 indicating minimal-slight-moderate-marked-massive, respectively.

Group	Placebo	Cinaciguat
N per group	9	2
Heart
N examined	9	2
Myocardial inflammatory infiltration	2	-
percent of tissues affected	22	-
average grade/tissues affected	1	-
Vasculopathy	6	1
percent of tissues affected	67	50
average grade/tissues affected	1.5	1.0
Myocardial fibrosis	8	2
percent of tissues affected	89	100
average grade/tissues affected	1.9	2.0
Lung
N examined	9	2
Peri-/Vasculitis	6	1
percent of tissues affected	67	50
average grade/tissues affected	1.2	2.0
Vasculopathy	4	1
percent of tissues affected	44	50
average grade/tissues affected	1.5	1.0
Kidneys
N examined	9	2
Glomerulopathy	9	2
percent of tissues affected	100	100
average grade/tissues affected	3.9	4.0
Tubulopathy	9	2
percent of tissues affected	100	100
average grade/tissues affected	4.0	4.0
Vasculopathy	9	1
percent of tissues affected	100	50
average grade/tissues affected	3.2	1.0
Inflammatory Infiltration	8	-
percent of tissues affected	89	0
average grade/tissues affected	2.0	-